UROP Project

3D-Bioprinting of Vascularized Organs-on-a-Chip

Contact

Name

Daniel Holder

Program Director UROP

Telephone

workPhone
+49 241 80-90695

E-Mail

Key Info

Basic Information

Project Offer-Number:
998
Category:
Keine eindeutige Zuordnung
Field:
Biomedical Engineering
Faculty:
4
Organisation unit:
Department of Biohybrid & Medical Textiles (BioTex), ITA-Institut für Textiltechnik
Language Skills:
English
Computer Skills:
Java (optional), CAD (optional)

Capillary network formation is a crucial step in the fabrication of living tissues and organs. In vitro growth of capillary-like structures has been frequently reported. However, inexistent guidance of capillary sprouting results in chaotic structures rather than the formation of an organized network. The aim of this project is to generate macroscopically structured capillary-like networks using 3D-bioprinting. The printed networks are applied as basis for the generation of tissue-like in vitro models.

Task

- Software and slicer optimization - Testing custom-built and commercial drop-on-demand bioprinter - Fabrication and characterization of cell-laden fibrin networks - Cell isolation and co-culture (HUVECs & hMSCs) - Microscopy

Requirements

Expertise in cell culture, robotics, microfluidics, programming skills