Key Info

Basic Information

Portrait: Prof. Dr. Laura De Laporte © Copyright: privat
Prof. Dr. Laura De Laporte
Faculty / Institution:
Mathematics, Computer Science and Natural Sciences
Organizational Unit:
Advanced Materials for Biomedicine Teaching and Research Area
Excellent Science
Project duration:
01.08.2021 to 31.01.2023
EU contribution:
150.000 euros
  EU flag and ERC logo This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 963675)  


Bioprinting Complex Tissue-mimicking Architectures


Over the past ten years, 3D bioprinting has emerged as a powerful tool to fabricate human tissue models ex vivo. These models can be used for drug discovery, to obtain a better understanding of physiological and pathological mechanisms, and in the future to replace diseased or injured tissues and organs. To successfully fabricate functional tissues, 3D bioprinted constructs should emulate the anatomical features of the native tissue’s extracellular matrix (ECM). However, current bioprinting technologies can neither mimic the nano- and microscale fibrillar ECM, nor replicate the anisotropic and spatially organized architecture and gradients of complex tissues, such as cartilage, cornea, and the heart. Within BioArchitecture, we aim to develop a novel 3D bioprinter platform, capable of bioprinting hierarchical and organized biomaterial constructs at high resolution to instruct and guide cell growth and tissue maturation. The BioArchitecture platform will allow researchers and pharmaceutical companies to perform better drugs target identification in native-like bioprinted human tissues ex vivo, which will better predict the efficacy and safety of the tested drugs and significantly decrease healthcare costs by reducing the required amount of personnel, infrastructure, an animal experiments associated to a new drug development.

Additional Information

This grant is hosted at DWI - Leibniz-Institut for Interactive Materials.