UROP Project

Neuromodulation of nociceptor afferents and its impact on brain responses and on the perception of pain

Contact

Name

Daniel Holder

Program Director UROP

Telephone

workPhone
+49 241 80-90695

E-Mail

Key Info

Basic Information

Project Offer-Number:
1096
Category:
Keine eindeutige Zuordnung
Field:
Psychology
Faculty:
10
Organisation unit:
Clinics for Psychiatry, Psychotherapy and Psychosomatics
Language Skills:
fluent in English; German skills are helpful but not mandatory

MoveOn

Chronic pain is a debilitating condition and one of the leading causes for patients to seek medical help. Yet it is not completely understood how long-lasting pain manifests in the brain nor are there adequate treatment options to help every sufferer. Previous studies have shown that stimulation with a so-called matrix electrode could lower pain sensitivity by inducing a form of synaptic long-term depression (LTD). On the other hand, the induction of synaptic long-term potentiation-like mechanisms (LTP) could serve as a model of hyperactivation of the pain system which is indicated in chronic pain states. In our study we aim to identify key brain networks after low- and high-frequency matrix electrode stimulation which is thought to induce states of LTD and LTP, respectively. We also want to evaluate whether perception of heat pain lessens after low frequency and whether it becomes more intense after high-frequency stimulation.

Task

Literature review, data analysis, preparation of EEG and fMRI, journal clubs, viewing talks by Senior Researchers, interdisciplinary exchange of information; students have the opportunity to participate in International Research Training Group 2150 - The Neuroscience of Modulating Aggression & Implusivity in Psychopathology

Requirements

Previous experience with EEG/fMRI is advantageous, but not necessary.