UROP Project

Neurofeedback based on real-time fMRI in patients with tic disorders



Daniel Holder

Program Director UROP


+49 241 80-90695


Key Info

Basic Information

Project Offer-Number:
Keine eindeutige Zuordnung
Organisation unit:
Department of Psychiatry, Psychotherapy and Psychosomatics
Language Skills:
Fluent in English
Computer Skills:
Basic knowledge of Word, Excel, MATLAB, SPM and SPSS is advantageous


Neurofeedback (NF) is an innovative paradigm, which has been increasingly discussed as a promising non-invasive therapeutic intervention in neuropsychiatric diseases and represents a powerful tool to explore the mechanisms underlying pathological brain-behavior-relationships. It allows participants to learn to regulate their own brain activity based on a feedback signal. One reliable method for making the neural information available for NF is real-time functional magnetic resonance imaging (rt-fMRI). In our study, using rt-fMRI NF, patients with tic disorders (TD) should learn to self-regulate the activity of a brain region, that is responsible for planning, initialization and execution of movements and implemented in the pathophysiology TD. The aim of this study is to investigate, if patients can learn to voluntarily regulate activity of the region of interest and if this leads to clinical improvement and symptom reduction in TD.


The intern participates in a project, that investigates the feasibility of fMRI neurofeedback as a therapeutic intervention. The intern will learn how to plan and design a neuroimaging study and how to conduct an fMRI experiment, from recruitment over clinical evaluations (e.g. psychological tests and behavioral measures) to acquiring fMRI data. Additionally, the student becomes an insight on how to analyze fMRI data using specialized software and evaluate and analyze neuropsychological tests.


A background in psychology, neuroscience, biology, or a related field is of importance. Knowledge in neuroimaging, statistics and SPM and SPSS software is of advantage, but not mandatory. The student should be highly motivated and interested in neuroimaging techniques (fMRI), experimental psychology and psychiatric disorders.