Spraying stem cells into the lung as new technique in the regenerative medicine
Program Director UROP
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- Project Offer-Number:
- RWTH UROP, UROP Network, UROP International
- Mechanical Engineering
- Organisation unit:
- Institute for Heat and Mass Transfer
- Language Skills:
- Fluent in English
- Computer Skills:
- Matlab, CAD (preferable SolidWorks)
- additional: OpenFoam, Ansys Fluent
Spraying stem cells is a new emerging technique in regenerative medicine for applying cells directly to the region of interest. By spraying stem cells directly into the lung, a significantly higher cell concentration on the injured lung tissue can be achieved than for conventional intravenous injections, where cells are homogeneously distributed in the blood flow and only reach the diseased areas via "tissue homing“. An air-assisted coaxial nozzle was developed which can be placed into the distal tip of the bronchoscope. This bronchoscopic nozzle allows the droplets, in which the cells are embedded, to be generated inside the lung instead of being supplied from the outside. This technique minimizes unwanted deposition in the upper airways. However, it must be ensured that the majority of the cells survive the spraying process. With an in-house developed lung model, it can be evaluated how far the droplets reach into the lung.
Depending on the interests of the student experimental work or numeric work i.e. CFD simulations are available. The experimental work includes building up and optimizing the experimental rig as well as testing the bronchoscopic nozzle within our lung model. Evaluations of the results are mostly done in Matlab. CFD simulations can be pursued on the lung model in order to better understand the lung flow and particle/droplet deposition.
The student should be able to work independently and accurately. Experience in Matlab and CAD programs are mandatory. CFD experience in OpenFoam or Ansys Fluent is preferable in the case of numerical work.