UROP Project

Neurofeedback training of frontostriatal control circuits for modification of obsessive-compulsivesymptoms in psychiatric diseases



Daniel Holder

Program Director UROP


+49 241 80-90695


Key Info

Basic Information

Project Offer-Number:
UROP International
Organisation unit:
Department of Psychiatry, Psychotherapy and Psychosomatics
Language Skills:
Fluent in English
Computer Skills:
Basic knowledge of Word, Excel, MATLAB, SPM and SPSS is advantageous


The fMRI study investigates brain plasticity after neuromodulation with real-time fMRI neurofeedback in the control of obsessive-compulsive symptoms. The target population is patients with obsessive-compulsive symptoms. During fMRI neurofeedback training, participants learn to consciously regulate connectivity between two brain regions in the fronto-striatal network, which are associated with intrusive thoughts. The goal is to improve obsessive-compulsive symptoms. In addition, the study will investigate the effect of the therapy method on resting-state networks in the brain. The present study aims to investigate, if participants can learn to self-monitor connectivity in the fronto-striatal network with real-time fMRI neurofeedback, if neurofeedback leads to changes in brain plasticity, and this leads to improvements in symptomatology.


The intern will participate in a project investigating the potential of fMRI neurofeedback as a therapeutic intervention. The intern will learn how to plan and design a neuroimaging study and how to conduct an fMRI experiment, from recruitment to clinical assessment (e.g., psychological testing and behavioral measures) to acquisition of fMRI data. In addition, the student will gain insight into the analysis of fMRI data using specialized software and the analysis of neuropsychological tests.


A background in psychology, neuroscience, biology or a related field is relevant. Knowledge of neuroimaging, statistics, MATLAB, SPM and SPSS software is an asset, but not required. The student should be highly motivated and interested in neuroimaging techniques (fMRI), experimental psychology, and psychiatric disorders.