Molecular basis of pheromone signaling in mice
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- Project Offer-Number:
- UROP Abroad
- Organisation unit:
- Harvard Medical School
- Language Skills:
Mouse pheromones are chemically diverse in structure and regulate a variety of innate behaviors, such as mating and aggression. Some mouse pheromones are detected by a specialized olfactory structure termed the vomeronasal organ (VNO). VNO sensory neurons express large families of G Protein-Coupled Receptors (GPCRs) that serve as chemosensory receptors. However, little is known about the molecular recognition properties of these VNO sensory receptors. Here, we will use a combination of molecular approaches and imaging to understand the molecular basis of VNO ligand recognition.
The student is learning a range of molecular biology techniques, including cloning, in situ hybridization, heterologous protein expression, and in collaboration with Marc Spehr's lab, neuronal imaging.
Basic experience in performing molecular biology protocols is required.
Harvard Medical School
240 Longwood Avenue, Department of Cell Biology