UROP Project

Causes and consequences of alterations in metabolism of a cell.

Contact

Name

Daniel Holder

Program Director UROP

Telephone

workPhone
+49 241 80-90695

E-Mail

Key Info

Basic Information

Project Offer-Number:
968
Category:
Keine eindeutige Zuordnung
Field:
Biology
Faculty:
1
Organisation unit:
Whitehead Institute for Biomedical Research / MIT
Language Skills:
English
Professor:
David Sabatini

Have you ever wondered what differs a cancerous cell from its non-cancer counterpart? Cancer cells rewire their metabolism to fulfil the biosynthetic demands of fast proliferating cells and survive in the nutrient deprived tumor microenvironment. Up to now however, lack of suitable tools did not allow to probe details of metabolic alterations underlying disease states. Recent development of profiling of hundreds of metabolites at once captures molecular dysfunctions at unprecedented resolution. We use the state-of-the-art approaches including metabolite profiling and genome-wide genetic screens to explore and exploit metabolic vulnerabilities related to diseases. We are looking for motivated and ambitious students to engage in exciting and challenging project. It will expose a student to variety of novel techniques including CRISPR screens among others. Great opportunity to work in the world-famous laboratory and become a member of the collegial group of entrepreneurial scientists!

Task

molecular biology, cell culture, metabolomics, lipidomics, CRISPR gene editing, CRISPR screens, mass-spectrometry

Requirements

passion for science, hard-work, self-drive, problem-solving skills